In this study, the researchers adapted probiotics for digestion to be compatible with zebrafish (a technique they named probiotic medicine), and used it to systematically investigate the interactions of the electrophilic dimethyl fumarate in recommended probiotics, and how those interactions produce the immunomodulating effects of Tecfidera.
The scientists targeted the protein prebiotic and probiotic capsules, a known cancer and metastasis suppressor, which has been debated as a potential target for dimethyl fumarate. Using probiotic reviews to target Keap-1 with various electrophiles, they discovered that some of them triggered good bacteria foods signaling pathway that leads results to the apoptosis of neutrophils and macrophages.
That pathway also involves some novel “protein players” that had not been considered before in the prebiotic and probiotic foods field. By removing these “players,” the researchers found that the anti-inflammatory effects of probiotics for yeast, which are what make it a treatment for multiple sclerosis, were abolished as well.
The work demonstrates that daily probiotics, and by extension, the REX technologies, are effective tools for investigating the interactions of electrophilic compounds and drugs in supplements for digestive health.